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The Norfolk component of the European Prospective Investigation of Cancer (EPIC) recruited over 30,000 people from 1993 to 2000. EPIC-Norfolk participants are men and women who were aged between 40 and 79 when they joined the study and who lived in Norwich and the surrounding towns and rural areas. They have been contributing information about their diet, lifestyle and health through questionnaires and health checks over two decades.

Following baseline data collection the cohort has been followed up at 18 months by questionnaire, 3 years (1997-2000) – second health check and questionnaire, 10 years – health questionnaire , 13 years (2006-2011) – third Health examination and questionnaire.

The primary aim of the ten country half a million international EPIC collaboration is to examine the relationships between diet and incident cancers; that is, cancers which have developed after they joined the study. This broadened to include lifestyle and genetic factors and other diseases

A secondary aim is to study the relationship between dietary intake and other diseases and disease risk factors. In EPIC-Norfolk, these include heart attacks and strokes, rheumatoid arthritis, diabetes, thyroid disease, osteoporosis, dementia, eye diseases and many others. We are also studying the link between disease and other factors, such as psychosocial health.

EPIC Norfolk is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research.

Last update: 07/12/2017

The University of Michigan Health and Retirement Study (HRS) is a longitudinal panel study that surveys a representative sample of approximately 20,000 people in the United States.

Last update: 21/01/2017

The OPDC Discovery cohort is a prospective, longitudinal study that has recruited patients with early idiopathic Parkinson Disease, healthy controls and participants at risk of PD. The study also includes participants with REM Sleep Behaviour Disorder. Over 1500 subjects have been recruited to the cohort, including 1087 people with Parkinson’s, 300 healthy controls, 111 First degree PD relatives and 151 PSG-diagnosed REM sleep behaviour disorder, thought to be ‘at-risk’ of developing future Parkinson’s. All patients have a clinical assessment repeated every eighteen months so we can better understand the progression of Parkinson’s over time. Over 500 patients have been seen for a second visit which has allowed us to identify some important differences in the way Parkinson’s progresses in different people.

Last update: 29/12/2016

In May 2006 a multidisciplinary team in the Institute for Ageing and Health at Newcastle University began a major groundbreaking study of the lives of those aged 85 years and older.
The study aimed to:

  • Assess, in great detail, the spectrum of health in the oldest old.
  • Examine the associations of health trajectories and outcomes with biological, clinical and social factors as the cohort ages.
  • Identify factors which contribute to the maintenance of health and independence.
  • Advance understanding of the biological nature of human ageing.

Eligible individuals will be all those who turn 85 during the year 2006 (i.e. born in 1921) and who are registered with a Newcastle or North Tyneside general practice. Participants will be visited in their current residence (own home or institution) by a research nurse at baseline, 18 months and 36 months. The assessment protocol entails a detailed multi-dimensional health assessment together with review of general practice medical records. Participants will be flagged with the NHS Central Register to provide details of the date and cause of death.

Last update: 17/01/2017

The NSHD has informed UK health care, education and social policy for more than 70 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of 13,687 of all births recorded in England, Scotland and Wales during one week of March, 1946, a socially stratified sample of 5,362 singleton babies born to married parents was selected for follow-up. This sample comprises the NSHD cohort and participants have been studied 24 times throughout their life.

During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and how these change with age.

Now, as participants reach retirement, the research team is developing the NSHD into a life course study of ageing. Study members completed a postal questionnaire in 2014 and participated in a home visit in 2015/16, where data on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements were collected. Over the past two years, a subset of 500 study members were invited to participate in a neuroimaging sub-study and over the next two years they will be recalled for a follow-up. This study will be conducted in collaboration with the Institute of Neurology, UCL.

NSHD is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK’s longitudinal studies.
NSHD is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-uk

Last update: 19/12/2016