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The West of Scotland Twenty-07 Study: ‘Health in the community’ was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, the place where people live, age, ethnic group and family type.

The basic design of the Study involved recruiting three cohorts (groups) of volunteers, each group born twenty years apart. Members of the oldest cohort were born around 1932, those in the middle cohort were born in 1952, and those in the youngest cohort were born in 1972. A total of 4,510 people agreed to take part, and have been followed for 20 years. The final wave of data collection was completed in 2008. This means that when the Study began (1987/8) participants were 15, 35 or 55 years old, and by the end of the Study (2007/8), participants were 35, 55 and 75 years old.
The data collected are extensive and include self-reported mental and physical health (including chronic conditions, medications, disabilities); physical measures; biomarkers; cognition; life circumstances (including employment, housing, family); health behaviours; beliefs, attitudes and values. The cohort is being followed up for mortality using linkage to national records. Any data on neurodegenerative disease are from self-reported health and / or death certificates.
A full description of the cohort profile is available in the following publication: Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009;38:1215-23

The VLS is a long-term, large-scale, and multi-faceted longitudinal investigation of human aging. Incorporating biomedical approaches, leading-edge technologies, and epidemiological perspectives, the VLS evaluates and tracks actual cognitive, health, functional and lifestyle trajectories leading to outcomes that can be classified as normal, resilient, exceptional, impaired, or dementia. Our studies examine these differential brain and cognitive changes as a function of interactions among multiple biomarkers of both risk and protection. Among these dynamically interacting biomarkers are those representing selected aspects of biological, health, genetic, metabolic, vascular, lifestyle, physical fitness, cognitive activity, sex/gender, and demographic domains

The Concord Health and Ageing in Men Project (CHAMP) is one of the worlds largest and most comprehensive study of the health of older men ever conducted anywhere in the world. CHAMP involves 1705 men aged 70 years and older recruited from the community living near Concord Hospital in Sydneys inner west. Subjects were recruited during 2005 and 2006 and subjects were re-assessed after two, five and nine years. A 14 year follow-up assessment (wave 5) is planned for 2019. Clinical dementia assessment was done at baseline but not in waves 2, 3, and 4. Clinical dementia assessment will be included in wave 5.

The study is particularly concerned with cognitive impairment and dementia; falls, fractures and osteoporosis; and urinary problems.

Korea became an ageing society in 2000, as the proportion of those 65 or older reached 7% of the population. Thereafter, the country is expected to undergo a rapid ageing process. Korea was belated compared to other advanced countries in reaching the ageing society status, but it is expected to become a super-aged society around the same time as others.

Lacking in basic data on ageing, Korea is in need of a structured set of statistical data. – Institutional reform and policy-making in preparation against the aged society require systematic build-up of data that can track individuals’ labor participation, income and asset status, spending patterns, retirement decisions, impact of social welfare, health, and intra-family transfer of income, among others.

The purpose of KLoSA is to create the basic data needed to devise and implement effective social, economic policies to address the trends that emerge in the process of population ageing.

The data will help identify and observe different dimensions of an aged society, build datasets that enable studies in different fields, and generate data comparable with similar panel studies in other countries (eg. U.S., Europe) that can provide the basis for policy-making and academic studies.

The Andhra Pradesh Children and Parent Study (APCAPS) is a large prospective, intergenerational cohort study in Southern India that began with the long-term follow-up of the Hyderabad Nutrition Trial (1987-1990). It is situated in 29 villages near the city of Hyderabad in Ranga Reddy district, Andhra Pradesh.

The Hyderabad Nutrition Trial evaluated the Integrated Child Development Services (ICDS) scheme, a national community outreach program, which provides a daily food supplement to pregnant women and children under 6 years of age. The trial used a controlled stepped wedge design, recruiting pregnant women from 29 villages (15 intervention with program; 14 controls awaiting implementation) and followed them through to childbirth.

In 2003-5, trial households were retraced and surveyed: families with at least one child born during the trial period and still alive in 2003-05 became the APCAPS prospective cohort (1815 families, 2601 index children). At this time, a first wave (W1) of data collection was carried out on index children and their mothers. The index children were then re-examined as young adults (aged 18-23 years) in 2009-10 (the second wave, W2) and then again in 2010-12 (the third wave, W3) when their siblings and parents were also examined. A socio-demographic household survey of all residents in all 29 villages was completed between 2012 and 2014.

ASPREE is a double-blind, randomized, placebo-controlled primary prevention trial designed to assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy participants aged 70 years and above except for Hispanic and African American minority groups in the U.S. where the minimum age of entry is 65 years.

The primary objective is to determine whether low-dose aspirin prolongs life, or life free of dementia, or life free of significant, persistent physical disability in the healthy elderly. Secondary objectives relate to the effects of low-dose aspirin on the key outcome areas of death, cardiovascular disease, dementia and cognitive decline, cancer, physical disability, depression and major bleeding episodes. Variables were collected annually through visits and for the purposes of retention telephone calls were scheduled at set points through the 7 years.

The Chinese Longitudinal Healthy Longevity Study (CLHLS) is a large-scale population-based study on health status and quality of life of the elderly in 23 provinces (out of 31 provinces) of China since 1998 with 8 waves so far. The study covers approximately 85% of the total population of China and was conducted to shed light on the determinants of human healthy longevity. The CLHLS tried to interview all consenting centenarians in the sampled counties and cities. For each centenarian interviewee, compatible nearby un-related elderly and younger participants were interviewed, including about one nonagenarian aged 90-99, one octogenarian aged 80-89, 1.5 young-old adult aged 65-79 and 0.7 middle-aged adult aged 40-64. Detailed longitudinal data on physical and mental health, cognitive function, social participation, etc. at old ages were collected from a total of 96,805 face-to-face interviews with 16,557 centenarians, 23,081 nonagenarians, 25,842 octogenarians, 19,650 younger elders aged 65-79, and 11,675 aged 35-64 in the completed 7 waves from 1998 to 2014. For the 26,701 participants who died between these seven waves, data on mortality and quality of life before death (i.e., degree/length of disability and suffering before death) were collected in interviews with a close family member of the deceased. The completed seven waves of CLHLS had collected DNA samples from 24,693 participants, including 4,849 centenarians, 5,190 nonagenarians, 5,274 octogenarians, 4,770 aged 65-79, and 4,609 aged 40-64. The 8th wave of CLHLS is ongoing and expected to be completed by the end of July 2018.

A family-based cohort study that is embedded in the Genetic Research in Isolated Populations (GRIP) program in the South West of the Netherlands. The aim of this program was to identify genetic risk factors in the development of complex disorders. For the ERF study, 22 families that had at least five children baptized in the community church between 1850-1900 were identified with the help of genealogical records. All living descendants of these couples and their spouses were invited to take part in the study. Data collection started in June 2002 and was finished in February 2005 (n=2065).

The primary objective of the Jackson Heart Study is to investigate the causes of cardiovascular disease (CVD) in African Americans to learn how to best prevent this group of diseases in the future.

Specific objectives include:
Identification of factors, which influence the development, and worsening of CVD in African Americans, with an emphasis on manifestations related to high blood pressure (such as remodeling of the left ventricle of the heart, coronary artery disease, heart failure, stroke, and disorders affecting the blood vessels of the kidney).
Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies.
Attracting minority students to and preparing them for careers in health sciences.

The Jackson Heart Study conducted three cohort examinations, an initial clinic examination from 2000 to 2004 (Exam1), followed by a second exam from 2005 to 2008 (Exam 2) and a final exam in 2009 to 2013 (Exam 3). Starting in 2001, participants have been contacted annually, and ascertainment of hospitalizations for cardiovascular events and deaths is ongoing.

Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).

We collect the below listed data at enrolment and then collect vital status, hospitalization, changes in meds and diagnoses, cognitive function (TICS) and physical function (IADS, ADL) over the phone, annually. Local subjects are asked to undergo annual detailed cognitive function testing in person with ultimately, brain donation. Blood sample collected at enrolment for DNA, RNA and plasma for biomarkers and storage.

Study is open to collaborations. Please contact Dr. Perls