Evidence from a meta-analysis of voxel-based morphometry studies

The number of people with Parkinson’s disease (PD) who have cognitive symptoms is difficult to pinpoint, mainly due to the use of various definitions of cognitive impairment and dementia.  Realistic estimates suggest that at least 50% of people with Parkinson’s have some mild cognitive impairment, with as many as 20-40% with more severe symptoms or dementia. Another problem is that PD often overlaps with other degenerative brain disorders that can cause dementia, such as Alzheimer disease and vascular disease.
This study gives further insight into the pathophysiological basis revealed by the brain structure abnormalities in Parkinson’s disease dementia.  The meta-analysis from this review provides strong evidence of Parkinson’s Disease-related brain atrophy in the medial temporal lobe and the basal ganglia areas of the brain, thus implicating these areas in Parkinson’s disease with Dementia.

Pubmed link is below:




December 15, 2012