A CALL FOR LARGE SCALE ANALYSIS OF OMICS DATA FOR DRUG-TARGET FINDING IN NEURODEGENERATIVE DISEASES

On January 4, 2023, the EU Joint Programme – Neurodegenerative Disease Research (JPND) initiative launched a transnational call for large scale analysis of OMICS data for drug-target finding in neurodegenerative diseases.

Neurodegenerative diseases are debilitating and largely untreatable conditions that are strongly linked with age. Worldwide, there are estimated to be 50 million people with Alzheimer’s disease and related disorders. This figure is expected to double every 20 years as the population ages. The total direct and informal care costs of Alzheimer’s, Parkinson’s and related disorders are expected to surpass €350 billion per year across the European Union. Existing treatments for neurodegenerative diseases are limited and mainly address the symptoms rather than the cause or the progressive course. With this in mind, JPND has identified a pressing need for investment aimed at enabling research projects on large scale analysis of Omics data for drug-target finding in neurodegenerative diseases.

Despite several remarkable achievements and advances in technology made during the past years, the pathophysiology of neurodegenerative diseases remains elusive. Recent studies show that diseases are complex and multifactorial, presenting hurdles to discover novel therapies. Access to current data and biomaterials from animal and cellular models and patients and targeted acquisition of new data opens the opportunity to explore changes at epigenetic, transcriptomic, proteomic, metabolomic, and lipidomic levels in a more comprehensive way. The data obtained from multi-omics studies analysed with the methods of systems biology can further elucidate the connection between the contributing factors and disease pathophysiology. The identified cellular changes from the multi-omics studies may be translated to animal and cellular models and to the human situation to study the disease mechanisms. This will permit novel strategies for validation of clinical therapeutic approaches.

JPND is therefore launching a joint transnational call with the aim of improving the understanding of the complex and multifactorial pathogenesis of neurodegenerative diseases through multi-OMICS and Big Data approaches designed to find new drug targets and target biomarkers for the development of tailored and personalised treatment approaches.

This transnational call invites proposals for ambitious, innovative, multi-disciplinary and multi-national collaborative research projects that seek to improve the understanding of the complex and multifactorial pathogenesis of neurodegenerative diseases by applying multi-OMICs and Big data approaches to generate useful information for the diagnosis, treatment, prognosis, and drug discovery of neurodegenerative diseases.

Funding: The total made available for this call is about 16.5 million euros.

Participating JPND Countries

The funding organisations that have agreed to fund this joint call for multinational research projects, with a view to adding value to their existing nationally funded activities, are listed below.

  • Austria, Austrian Research Promotion Agency on behalf of BMBWF (FFG)
  • Belgium, The Fund for Scientific Research (F.R.S.-FNRS)
  • Canada, Canadian Institutes of Health Research (CIHR)
  • Czech Republic, Ministry of Education, Youth and Sports (MEYS)
  • France, French National Research Agency (ANR)
  • Germany, Federal Ministry of Education and Research (BMBF)
  • Hungary, National Research, Development and Innovation Office (NKFIH)*
  • Ireland, Health Research Board (HRB)
  • Israel, Ministry of Health (CSO-MOH)
  • Italy, Ministry of Health (MOH-IT)
  • Luxembourg, National Research Fund (FNR)
  • Netherlands, The Netherlands Organisation for Health Research and Dev. (ZonMw) and Alzheimer Nederland
  • Poland, National Science Centre (NCN)
  • Slovakia, Ministry of Education, Science, Research and Sport of the Slovak Republic (MESR)
  • Spain, Institute of Health Carlos III (ISCIII)
  • Sweden, Swedish Research Council (SRC)
  • Switzerland, Swiss National Science Foundation (SNSF)
  • Turkey, Scientific and Technological Research Council of Turkey (TUBITAK)*

* Decision pending

Deadline: 

Pre-proposals must be submitted no later than 12:00h C.E.T. on March 7, 2023, via the electronic submission tool.

Where can I get more information about this call? Links to the relevant documents and resources can be found below:

Call text** – download all specific information about the call. [PDF]

Call procedures – description of the evaluation procedure and decision-making process applied for this call. [PDF]

Country-specific information – all requirements and details from participating funding organisations. [PDF]

Pre-proposal template – mandatory for creating proposals. No other formats are accepted.

Proposal Submission Tool – mandatory for submitting proposals. No other routes are accepted.

**Updated as of 19/01/2023

Joint Call Secretariat representatives are available for questions:

Sabrina Voß and Sara Breid

Phone: (+49) 228-3821 2111
Email: [email protected]

In case you will not apply but are interested in supporting this JPND call as an expert reviewer, please contact us via email.