Linking Pre-Diagnosis Disturbances of Physiological Systems to Neurodegenerative Diseases Projects

Call Results

Results of the 2021 JPND Call for “Linking Pre-Diagnosis Disturbances of Physiological Systems to Neurodegenerative Diseases”

The fourteen projects were recommended for funding* by an independent, international Peer Review Panel based on scientific excellence with input from the JPND advisory board on patient and public involvement. Proposals are presented in alphabetical order according to their acronym.

*Please note this is a provisional decision. The final approval from national funding agencies is still ongoing.

ADIS
Early Diagnosis of Alzheimer’s Disease by Immune Profiling of Cytotoxic Lymphocytes and Recording of Sleep Disturbances

Coordinator:
Holger Fröhlich, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Germany

Partners:
Raquel Sanchez-Valle, Fundació Clínic per a la Recerca Biomèdica (FCRB), Spain
Uri Nevo, Tel Aviv University (TAU), Israel
Jean Georges, Alzheimer Europe (AE), Luxembourg
Stefan Kirsch, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM-R), Germany
Istvan Nagy, SeqOmics Biotechnology Ltd. (SO), Hungary

CONTROL-PD
COgNiTive propagation in pRodrOmaL Parkinson’s disease

Coordinator:
Rick Helmich, Radboud University Medical Centre & Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Centre for Cognitive Neuroimaging, Netherlands

Partners:
Stephane Lehericy, Hôpital Pitié-Salpêtrière, ICM – Paris Brain Institute, Paris, France
Alain Dagher, McGill University, Montreal Neurological Institute, Montreal, Canada
Anat Mirelman, Tel-Aviv Sourasky Medical Centre, Neurological Institute, Tel Aviv, Israel
Simon Lewis, University of Sydney, Brain and Mind Centre, Sydney, Australia
Norbert Bruggemann, University of Lubeck, Institute of Neurogenetics, Lubeck, Germany
Romain Ligneul, Robust Circuit, Lisbon, Portugal

EPIC4ND
Disease prediction for Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis using methylome profiling: the EPIC4ND study

Coordinator:
Christina Lill, University of Münster, Münster, Germany

Partners:
Roel Vermeulen, Utrecht University, Netherlands
Marc Gunter, International Agency for Research on Cancer, France
Sture Eriksson, Umeå Unversity, Sweden
Johnni Hansen, Danish Cancer Society, Denmark

HBCI
Human brain clearance imaging (HBCI): a window on physiological disturbances in the pre- diagnostic phase of neurodegenerative diseases

Coordinator:
M.J.P. van Osch, Leiden University Medical Center, Academic Hospital, Netherlands

Partners:
A. Eklund, Umeå University, University and University Hospital, Sweden
M. Nedergaard, University of Copenhagen, University, Denmark
A. Radbruch, University of Bonn, University and University Hospital, Germany
G. Ringstad, Oslo University Hospital, Academic Hospital, Norway

Iron Sleep
Early stage neuroimaging and behavioral biomarkers of PD progression and underlying mechanisms

Coordinator:
Nikolaus Weiskopf, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig

Partners:
Anneke Alkemade, University of Amsterdam, Amsterdam
Gilles Vandewalle, Université de Liège, Belgium
Norbert Kovács, University of Pécs, Hungary

LeMeReND
Leveraging medical records to identify patients at risk of neurodegenerative disease

Coordinator:
Stanley Durrleman, Paris Brain Institute, France

Partners:
Allan McRae, The University of Queensland, Australia
Fang Fang, Karolinska Institutet (KI), Sweden
Bruno Ventelou, Université Aix-Marseille, France

MINDFACE
MIcroglial early Neuroinflamatory Dysfunction in Fontotemporal Dementia and Amyotrophic Lateral Sclerosis due to C9orf72 repeat Expansions

Coordinator:
John C. van Swieten, Erasmus University Medical Centre, Netherlands

Partners:
Bart J.L. Eggen, University Medical Center Groningen, Netherlands
Peter Heutink, German Center for Neurodegenerative Diseases, Tubingen (DZNE), GermanyIsabelle LeBer, Paris Institute Hopital de la Salpetriere, Paris, France
Paola Caroppo, Fondazione IRCCS, Instituto Neurologico Carlo Besta, Milan, Italy

PD-PAM
Early indicators of nervous system dysfunction in gut-first and brain-first animal models of Parkinson’s Disease

Coordinator:
Nathalie Van Den Berge, Aarhus University, Denmark

Partners:
Fanni F. Geibl, Philipps-University Marburg, Germany
Peter Nilsson, Linköping University, Sweden
Mikael Lindgren, Norwegian University of Science and Technology, Norway
Ayça Arslan-Ergül, Bilkent University UNAM, Turkey

premodiALS
A premotor disease signature for ALS

Coordinator:
Lingor, Klinikum rechts der Isar der TU München, Germany

Partners:
Menden, Helmholz-Zentrum München, Germany
Weber, ALS-Clinic St. Gallen, Switzerland
Corcia, CHU Tours, France
Lerner, Hebrew University – Hadassah Medical Center Jerusalem, Israel
Ashton, Gothenburg University, Sweden
Kuban, Maj Institute of Pharmacology, PAS, Kraków, Poland

Press AD
Presymptomatic synaptic disorders in Alzheimer’s disease

Coordinator:
Christophe Mulle, CNRS/University of Bordeaux, France

Partners:
Ann Brinkmalm, Sahlgrenska Academy, University of Gothenburg, Sweden
Matthijs Verhage, CNCR/Vrije Universiteit, Amsterdam, Netherlands
Michalina Wężyk, Mossakowski Medical Research Institute Polish Academy of Sciences, Poland
Gabor Tamas, University of Szeged, Hungary

ProFFlle
Prodromal biomarkers in fatal familial insomnia: a longitudinal study in humans and mice

Coordinator:
Roberto Chiesa, Istituto di Ricerche Farmacologiche Mario Negri, Italy

Partners:
Inga Zerr, Universitätsmedizin Göttingen, Academia, Germany
Joaquin Castilla, Asociación Centro de Investigación Cooperativa en Biociencias, Spain
Izaro Kortazar, Hospital Universitario Araba, Spain
Fabio Moda, Fondazione IRCCS Istituto Neurologico Carlo Besta, Italy

SOLID
Risk factors and markers for early detection of Alzheimer’s Disease: focus on early-life adversity, inflammation and lipid mediators

Coordinator:
Sarah J. Spencer; RMIT University, Australia

Partners:
Aniko Korosi, University of Amsterdam, Netherlands
Luba Sominsky, Barwon Health, Deakin University, Australia
Sophie Layé, NutriNeuro, Inrae, Bordeaux University, France
Christoph Rummel, Justus Liebig University Giessen, CMBB, Germany
Frédéric Calon, Laval University, Quebec, Canada
Péter Antal; Budapest University of Technology and Economics, Hungary

SynaDeg
Prediagnostic early synaptic disturbances in neurodegenerative diseases

Coordinator:
Annakaisa Haapasalo, University of Eastern Finland, Kuopio, Finland

Partners:
Anne M. Remes, University of Oulu, Oulu, Finland
Olivia Belbin, Fundació Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Peter Heutink, German Center for Neurodegenerative Diseases, Tübingen, Germany
Henrik Zetterberg, University of Gothenburg, Sweden

TACKL-PRED
TACKLing the challenges of PREsymptomatic sporadic Dementia

Coordinator:
Mario Masellis, Sunnybrook Health Sciences Centre/University of Toronto, Canada

Partners:
Arfan Ikram, Erasmus University Medical Centre Rotterdam, Netherlands
Hlin Kvartsberg, University of Gothenburg, Sweden
Irena Rektorova, Masaryk University, Czech Republic