Call Results

Results of the 2021 JPND Call for “Linking Pre-Diagnosis Disturbances of Physiological Systems to Neurodegenerative Diseases”

The fourteen projects were recommended for funding* by an independent, international Peer Review Panel based on scientific excellence with input from the JPND advisory board on patient and public involvement. Proposals are presented in alphabetical order according to their acronym.


*Please note this is a provisional decision. The final approval from national funding agencies is still ongoing. 

Early Diagnosis of Alzheimer’s Disease by Immune Profiling of Cytotoxic Lymphocytes and Recording of Sleep Disturbances

Holger Fröhlich, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Germany

Raquel Sanchez-Valle, Fundació Clínic per a la Recerca Biomèdica (FCRB), Spain
Uri Nevo, Tel Aviv University (TAU), Israel
Jean Georges, Alzheimer Europe (AE), Luxembourg
Stefan Kirsch, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM-R), Germany
Istvan Nagy, SeqOmics Biotechnology Ltd. (SO), Hungary


COgNiTive propagation in pRodrOmaL Parkinson’s disease

Rick Helmich, Radboud University Medical Centre & Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Centre for Cognitive Neuroimaging, Netherlands

Stephane Lehericy, Hôpital Pitié-Salpêtrière, ICM – Paris Brain Institute, Paris, France
Alain Dagher, McGill University, Montreal Neurological Institute, Montreal, Canada
Anat Mirelman, Tel-Aviv Sourasky Medical Centre, Neurological Institute, Tel Aviv, Israel
Simon Lewis, University of Sydney, Brain and Mind Centre, Sydney, Australia
Norbert Bruggemann, University of Lubeck, Institute of Neurogenetics, Lubeck, Germany
Romain Ligneul, Robust Circuit, Lisbon, Portugal


Disease prediction for Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis using methylome profiling: the EPIC4ND study

Christina Lill, University of MünsterMünster, Germany

Roel Vermeulen, Utrecht University, Netherlands
Marc Gunter, International Agency for Research on Cancer, France
Sture Eriksson, Umeå Unversity, Sweden
Johnni Hansen, Danish Cancer Society, Denmark


Human brain clearance imaging (HBCI): a window on physiological disturbances in the pre- diagnostic phase of neurodegenerative diseases

M.J.P. van Osch, Leiden University Medical Center, Academic Hospital, Netherlands

A. Eklund, Umeå University, University and University Hospital, Sweden
M. Nedergaard, University of Copenhagen, University, Denmark
A. Radbruch, University of Bonn, University and University Hospital, Germany
G. Ringstad, Oslo University Hospital, Academic Hospital, Norway


Iron Sleep
Early stage neuroimaging and behavioral biomarkers of PD progression and underlying mechanisms

Nikolaus Weiskopf, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig

Anneke Alkemade, University of Amsterdam, Amsterdam
Gilles Vandewalle, Université de Liège, Belgium
Norbert Kovács, University of Pécs, Hungary


Leveraging medical records to identify patients at risk of neurodegenerative disease

Stanley Durrleman, Paris Brain Institute, France

Allan McRae, The University of Queensland, Australia
Fang Fang, Karolinska Institutet (KI), Sweden
Bruno Ventelou, Université Aix-Marseille, France


MIcroglial early Neuroinflamatory Dysfunction in Fontotemporal Dementia and Amyotrophic Lateral Sclerosis due to C9orf72 repeat Expansions

John C. van Swieten, Erasmus University Medical Centre, Netherlands

Bart J.L. Eggen, University Medical Center Groningen, Netherlands
Peter Heutink, German Center for Neurodegenerative Diseases, Tubingen (DZNE), GermanyIsabelle LeBer, Paris Institute Hopital de la Salpetriere, Paris, France
Paola Caroppo, Fondazione IRCCS, Instituto Neurologico Carlo Besta, Milan, Italy


Early indicators of nervous system dysfunction in gut-first and brain-first animal models of Parkinson’s Disease

Nathalie Van Den Berge, Aarhus University, Denmark

Fanni F. Geibl, Philipps-University Marburg, Germany
Peter Nilsson, Linköping University, Sweden
Mikael Lindgren, Norwegian University of Science and Technology, Norway
Ayça Arslan-Ergül, Bilkent University UNAM, Turkey


A premotor disease signature for ALS

Lingor, Klinikum rechts der Isar der TU München, Germany

Menden, Helmholz-Zentrum München, Germany
Weber, ALS-Clinic St. Gallen, Switzerland
Corcia, CHU Tours, France
Lerner, Hebrew University – Hadassah Medical Center Jerusalem, Israel
Ashton, Gothenburg University, Sweden
Kuban, Maj Institute of Pharmacology, PAS, Kraków, Poland


Press AD
Presymptomatic synaptic disorders in Alzheimer’s disease

Christophe Mulle, CNRS/University of Bordeaux, France

Ann Brinkmalm, Sahlgrenska Academy, University of Gothenburg, Sweden
Matthijs Verhage, CNCR/Vrije Universiteit, Amsterdam, Netherlands
Michalina Wężyk, Mossakowski Medical Research Institute Polish Academy of Sciences, Poland
Gabor Tamas, University of Szeged, Hungary


Prodromal biomarkers in fatal familial insomnia: a longitudinal study in humans and mice

Roberto Chiesa, Istituto di Ricerche Farmacologiche Mario Negri, Italy

Inga Zerr, Universitätsmedizin Göttingen, Academia, Germany
Joaquin Castilla, Asociación Centro de Investigación Cooperativa en Biociencias, Spain
Izaro Kortazar, Hospital Universitario Araba, Spain
Fabio Moda, Fondazione IRCCS Istituto Neurologico Carlo Besta, Italy


Risk factors and markers for early detection of Alzheimer’s Disease: focus on early-life adversity, inflammation and lipid mediators

Sarah J. Spencer; RMIT University, Australia

Aniko Korosi, University of Amsterdam, Netherlands
Luba Sominsky, Barwon Health, Deakin University, Australia
Sophie Layé, NutriNeuro, Inrae, Bordeaux University, France
Christoph Rummel, Justus Liebig University Giessen, CMBB, Germany
Frédéric Calon, Laval University, Quebec, Canada
Péter Antal; Budapest University of Technology and Economics, Hungary


Prediagnostic early synaptic disturbances in neurodegenerative diseases

Annakaisa Haapasalo, University of Eastern Finland, Kuopio, Finland

Anne M. Remes, University of Oulu, Oulu, Finland
Olivia Belbin, Fundació Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Peter Heutink, German Center for Neurodegenerative Diseases, Tübingen, Germany
Henrik Zetterberg, University of Gothenburg, Sweden


TACKLing the challenges of PREsymptomatic sporadic Dementia

Mario Masellis, Sunnybrook Health Sciences Centre/University of Toronto, Canada

Arfan Ikram, Erasmus University Medical Centre Rotterdam, Netherlands
Hlin Kvartsberg, University of Gothenburg, Sweden
Irena Rektorova, Masaryk University, Czech Republic